Translational Medicine

A groundbreaking study from Johns Hopkins Medicine reveals that older adults with cancer respond just as well as younger patients to immune checkpoint inhibitors (ICIs)—a class of life-saving cancer immunotherapy drugs. This promising discovery counters longstanding concerns that age-related immune system changes might reduce treatment effectiveness in elderly patients.

A groundbreaking study by researchers at West China Hospital, Sichuan University, has unveiled a previously unknown mechanism linking Epstein–Barr virus (EBV) infection to the worsening of ulcerative colitis (UC). Published in Precision Clinical Medicine on January 21, 2025 (DOI: 10.1093/pcmedi/pbaf002), the research reveals that EBV can trigger inflammatory cell death—known as pyroptosis—in macrophages, a discovery that may pave the way for new, targeted treatments for UC.