Precision Medicine

In a pioneering study published in Biological Psychiatry by Elsevier, scientists have conducted the first comprehensive single-cell analysis of brain tissue from individuals with Tourette syndrome. The findings offer unprecedented clarity into which specific brain cells are affected by the condition and how they malfunction—offering the most detailed cellular map of the syndrome to date. Conducted by researchers at Yale University, the Mayo Clinic, and the National Human Genome Research Institute (NHGRI), the study could mark a turning point in how Tourette syndrome is understood and treated.

A groundbreaking study from Baylor College of Medicine has uncovered a novel mechanism by which triple negative breast cancer (TNBC) evades treatment—through the accumulation of specific fatty acids that suppress the immune response and drive therapy resistance.

In a groundbreaking phase 1 clinical trial at City of Hope®, one of the largest and most advanced cancer research and treatment centers in the U.S., researchers are exploring an innovative approach to treating rectal cancer. The trial seeks to transform rectal cancer—a disease notorious for its resistance to radiation—into a form that is much more responsive to radiation and chemotherapy. This new strategy, which uses the investigational drug papaverine, could pave the way for less invasive treatment options and dramatically improve the quality of life for patients.

An international team of researchers has explored how multi-omics—the integration of molecular data across different biological layers—can enhance our understanding of the way genetic and environmental factors interact to influence chronic diseases.