RosTrace

Tag: Preclinical research

Robin Hayes

Eliminating Hepatic Stellate Cells Halts Liver Metastasis in Mouse Models

In a landmark discovery published on June 10, 2025 in Hepatology Communications, researchers at the University of the Basque Country (EHU) have demonstrated that removing activated hepatic stellate cells (HSCs) from the liver virtually eliminates metastatic tumor growth in mouse models. The finding not only overturns long-held assumptions about the benign role of HSCs in liver repair but also identifies a promising new target for therapies aimed at preventing or treating liver metastases from a variety of primary cancers.

· 5 min read

Robin Hayes

Animal Study Uncovers Distinct Metabolic Effects of Tirzepatide Versus Semaglutide

New preclinical research presented at the 2025 European Congress on Obesity (ECO) in Malaga, Spain, reveals that the anti-obesity drugs tirzepatide and semaglutide produce markedly different short-term metabolic responses in mice. While tirzepatide transiently increases energy expenditure, semaglutide initially suppresses it. Both agents, however, converge on enhanced fat oxidation and appetite suppression, with the most pronounced metabolic shifts occurring during active treatment and rapidly waning once dosing ceases.

· 5 min read